张克娜,女,1990年生,药物化学博士,讲师,英国上市公司官网365/制药工程系讲师,国家公派留学生,电子邮箱:kena.zhang@xcu.edu.cn
一、学习经历:
2022.08-至今 英国上市公司官网365/制药工程系 讲师
2017.10-2021.10 法国巴黎萨克雷大学 药学院 治疗化学博士
2014.09-2016.07 郑州大学 化学与分子工程学院 有机化学硕士
2010.09-2014.06 郑州大学 化学与分子工程学院 化学学士
二、科学研究
主要研究方向:(1)有机合成方法学:C-H键活化,C-N键构筑等;(2)天然药物的结构修饰:CA-4(combretastatin A-4,康普立汀A-4)等。目前以第一作者身份共发表七篇SCI论文。
代表性科研论文:
Zhang, K.; Li, H.; Li, J.; Zou, D.;* Wu, Y.;* Wu, Y.,* An efficient palladium-catalyzed synthesis of 1-heteroaryl-4-aminopiperidine derivatives from heteroaryl chlorides. Tetrahedron Lett. 2017, 58, 1976-1979.
Zhang, K.; Bzeih, T.; Khalaf, A.; Hachem, A.; Alami, M.;* Hamze, A.,* One-Pot Reaction between N-Tosylhydrazones and 2-Nitrobenzyl Bromide: Route to NH-Free C2-Arylindoles. J. Org. Chem. 2019, 84, 228-238.
Zhang, K.; El Bouakher, A.; Levaique, H.; Bignon, J.; Retailleau, P.; Alami, M.;* Hamze, A.,* Pyrrolo-imidazo[1,2-a]pyridine Scaffolds through a Sequential Coupling of N-Tosylhydrazones with Imidazopyridines and Reductive Cadogan Annulation, Synthetic Scope, and Application. J. Org. Chem. 2019, 84, 13807-13823.
Zhang, K.; El Bouakher, A.; Lévaique, H.; Bignon, J.; Retailleau, P.; Alami, M.;* Hamze, A.,* Imidazodipyridines via DMAP Catalyzed Domino N−H Carbonylation and 6π‐Electrocyclization: Synthetic Scope and Application. Adv. Synth. Catal. 2020, 362, 3243-3256.
Zhang, K.; Provot, O.; Tran, C.; Alami, M.; Hamze, A.,* Copper-catalyzed sulfonylation of N-tosylhydrazones followed by a one-pot C-N bond formation. Org. Biomol. Chem. 2021, 19, 5358-5367.
Zhang, K.; Tran, C.; Alami, M.; Hamze, A.; Provot, O.,* Synthesis and Biological Activities of Pyrazino[1,2-a]indole and Pyrazino[1,2-a]indol-1-one Derivatives. Pharmaceuticals 2021, 14, 779.
Zhang, K.; Provot, O.; Alami, M.; Tran, C.;* Hamze, A.,* Pd-Catalyzed Coupling of N-Tosylhydrazones with Benzylic Phosphates: Toward the Synthesis of Di- or Tri-Substituted Alkenes. J. Org. Chem. 2022, 87, 1249-1261.
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